OriGene

Hex Monoclonal Antibody (OTI3F4 1B1), TrueMAB™

View all (32) Hex antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Hex Monoclonal Antibody (OTI3F4 1B1), TrueMAB™

Product Details

CF500099

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

OTI3F4 1B1

Immunogen

Recombinant fragment expressed in E.coli corresponding to amino acids 100-270 of human Hex
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

HHEX is a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. Establishes anterior identity at two levels 1) acts early to enhance canonical WNT-signaling by repressing expression of TLE4 and 2) acts later to inhibit NODAL-signaling by directly targeting NODAL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Hematopoietically-expressed homeobox protein HHEX; homeobox; Homeobox protein HEX; Homeobox protein PRH; homeobox, hematopoietically expressed; Proline-rich homeodomain protein; proline-rich homeodomain-containing transcription factor

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Gene Aliases: HEX; HHEX; HMPH; HOX11L-PEN; PRH; PRHX

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UniProt ID: (Human) Q03014

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Entrez Gene ID: (Human) 3087

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding protein binding transcription factor binding eukaryotic initiation factor 4E binding DNA binding, bending TBP-class protein binding protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding repressing transcription factor binding HMG box domain binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter vasculogenesis in utero embryonic development myeloid leukocyte differentiation transcription, DNA-templated mRNA export from nucleus Notch signaling pathway endoderm development cell proliferation anterior/posterior pattern specification negative regulation of transcription by transcription factor localization negative regulation of transcription by competitive promoter binding Wnt signaling pathway negative regulation of angiogenesis poly(A)+ mRNA export from nucleus interkinetic nuclear migration cell differentiation positive regulation of Wnt signaling pathway B cell differentiation thyroid gland development negative regulation of vascular endothelial growth factor receptor signaling pathway pancreas development protein localization to nucleus embryonic heart tube development multicellular organism growth regulation of cell proliferation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter forebrain morphogenesis primary lung bud formation gall bladder development hepatic duct development hepatoblast differentiation hepatocyte differentiation DNA conformation change primitive streak formation
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