Invitrogen

HRG Polyclonal Antibody

View all (14) HRG antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
HRG Polyclonal Antibody

Product Details

PA5-97051

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human HRG (NP_0004031)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.78 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808853

Product Specific Information

Immunogen sequence: SPTDCSAVEP EAEKALDLIN KRRRDGYLFQ LLRIADAHLD RVENTTVYYL VLDVQESDCS VLSRKYWNDC EPPDSRRPSE IVIGQCKVIA TRHSHESQDL RVIDFNCTTS SVSSALANTK DSPVLIDFFE DTERYRKQAN KALEKYKEEN DDFASFRVDR IERVARVRGG EGTGYFVDFS VRNCPRHHFP RHPNVFGFCR ADLFYDVEAL DLESPKNLVI NCEVFDPQEH ENINGVPPHL G; Positive Samples: Mouse pancreas

Target Information

HRG contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp779H1622; Histidine-proline-rich glycoprotein; Histidine-rich glycoprotein; Histidine-rich glycoprotein 1; HPRG; HRG1

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Gene Aliases: AI265597; AW413091; D16jh2; D18020; HPRG; Hrg; HRG1; Hrgp

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UniProt ID: (Rat) Q99PS8, (Mouse) Q9ESB3

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Entrez Gene ID: (Rat) 171016, (Mouse) 94175

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Function(s)
molecular_function serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity receptor binding heparin binding zinc ion binding immunoglobulin binding heme binding heparan sulfate proteoglycan binding metal ion binding protein binding
Process(es)
positive regulation of immune response to tumor cell negative regulation of cell adhesion biological_process negative regulation of cell proliferation regulation of gene expression regulation of platelet activation negative regulation of lamellipodium assembly negative regulation of endopeptidase activity response to organic cyclic compound heme transport negative regulation of angiogenesis platelet activation regulation of blood coagulation negative regulation of cell growth regulation of actin cytoskeleton organization negative regulation of cell adhesion mediated by integrin regulation of transcription from RNA polymerase II promoter in response to iron fibrinolysis positive regulation of apoptotic process regulation of protein complex assembly negative regulation of blood vessel endothelial cell migration regulation of peptidyl-tyrosine phosphorylation defense response to fungus positive regulation of focal adhesion assembly negative regulation of fibrinolysis heme export negative regulation of vascular endothelial growth factor signaling pathway positive regulation of blood vessel remodeling negative regulation of endothelial cell chemotaxis angiogenesis chemotaxis blood coagulation hemostasis
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