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  • HRG Antibodies

Invitrogen

HRG Polyclonal Antibody

View all (14) HRG antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite HRG Polyclonal Antibody

  • Antibody Testing Data (3)
HRG Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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HRG Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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HRG Antibody (PA5-79396) in IHC (P)

Immunohistochemistry analysis of HRG on paraffin-embedded human intestinal cancer tissue. Sample was incubated with HRG polyclonal antibody (Product# PA5-79396). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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HRG Antibody in Immunohistochemistry (Paraffin) (IHC (P))
HRG Antibody in Western Blot (WB)
HRG Antibody in Western Blot (WB)
HRG Polyclonal Antibody

Product Details

PA5-79396

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human HRG recombinant protein (Position: V19-V200).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746512

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: Human Placenta Tissue. IHC: Human Intestinal Cancer Tissue.

Target Information

HRG contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp779H1622; Histidine-proline-rich glycoprotein; Histidine-rich glycoprotein; HPRG

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Gene Aliases: HPRG; HRG; HRGP; THPH11

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UniProt ID: (Human) P04196

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Entrez Gene ID: (Human) 3273

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Function(s)
serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity receptor binding protein binding heparin binding zinc ion binding immunoglobulin binding heme binding heparan sulfate proteoglycan binding metal ion binding
Process(es)
angiogenesis platelet degranulation positive regulation of immune response to tumor cell chemotaxis negative regulation of cell adhesion negative regulation of cell proliferation regulation of gene expression regulation of platelet activation negative regulation of lamellipodium assembly negative regulation of endopeptidase activity heme transport negative regulation of angiogenesis platelet activation regulation of blood coagulation negative regulation of cell growth regulation of actin cytoskeleton organization negative regulation of cell adhesion mediated by integrin fibrinolysis positive regulation of apoptotic process regulation of protein complex assembly negative regulation of blood vessel endothelial cell migration regulation of peptidyl-tyrosine phosphorylation defense response to fungus positive regulation of focal adhesion assembly negative regulation of fibrinolysis negative regulation of vascular endothelial growth factor signaling pathway positive regulation of blood vessel remodeling negative regulation of endothelial cell chemotaxis
It has to be done as per old AB suggested Products section.
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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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