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Proteintech
HPD Polyclonal Antibody
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Product Details
17004-1-AP
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MTTYSDKGA KPERGRFLHF HSVTFWVGNA KQAASFYCSK MGFEPLAYRG LETGSREVVS HVIKQGKIVF VLSSALNPWN KEMGDHLVKH GDGVKDIAFE VEDCDYIVQK ARERGAKIMR EPWVEQDKFG KVKFAVLQTY GDTTHTLVEK MNYIGQFLPG YEAPAFMDPL LPKLPKCSLE MIDHIVGNQP DQEMVSASEW YLKNLQFHRF WSVDDTQVHT EYSSLRSIVV ANYEESIKMP INEPAPGKKK SQIQEYVDYN GGAGVQHIAL KTEDIITAIR HLRERGLEFL SVPSTYYKQL REKLKTAKIK VKENIDALEE LKILVDYDEK GYLLQIFTKP VQDRPTLFLE VIQRHNHQGF GAGNFNSLFK AFEEEQNLRG NLTNMETNGV VPGM (1-393 aa encoded by BC024287)
Target Information
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 4-H HPPDASE; 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4H GLOD3; 4HPPD; F Alloantigen; F liver antigen; F protein; glyoxalase domain containing 3; HPPDase
Gene Aliases: 4-HPPD; 4HPPD; Fla; Flp; GLOD3; HPD; Hppd; HPPDASE; Laf; PPD
UniProt ID: (Human) P32754, (Mouse) P49429, (Rat) P32755
Entrez Gene ID: (Human) 3242, (Mouse) 15445, (Rat) 29531
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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