OriGene

HEYL Monoclonal Antibody (OTI4D8), TrueMAB™

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Datasheet
Protocols
Questions & Answers
HEYL Monoclonal Antibody (OTI4D8), TrueMAB™

Product Details

TA812473

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

OTI4D8

Immunogen

Full length human recombinant protein of human HEYL produced in E.coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHb33; Class B basic helix-loop-helix protein 33; Hairy-related transcription factor 3; hairy/enhancer-of-split related with YRPW motif 3; Hairy/enhancer-of-split related with YRPW motif-like protein; hes-related family bHLH transcription factor with YRPW motif-like; HEY-like protein; hHeyL; hHRT3; HRT-3

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Gene Aliases: BHLHB33; HESR3; HEY3; HEYL; HRT3

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UniProt ID: (Human) Q9NQ87

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Entrez Gene ID: (Human) 26508

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Function(s)
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific transcription factor activity, protein binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding transcription factor binding microsatellite binding protein homodimerization activity protein heterodimerization activity AF-1 domain binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter outflow tract morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac ventricle morphogenesis transcription from RNA polymerase II promoter Notch signaling pathway mesenchymal cell development glomerulus development skeletal muscle cell differentiation positive regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cardiac epithelial to mesenchymal transition ventricular septum morphogenesis negative regulation of androgen receptor signaling pathway cellular response to BMP stimulus proximal tubule development negative regulation of androgen receptor activity
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