Invitrogen

HEYL Polyclonal Antibody

View all (19) HEYL antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
HEYL Polyclonal Antibody

Product Details

PA5-85014

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human HEYL. Recombinant protein control fragment (Product #RP-108673).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792163

Product Specific Information

Immunogen sequence: MKRPKEPSGS DGESDGPIDV GQEGQLSQMA RPLSTPSSSQ MQARKKHRGI I

Target Information

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHb33; Class B basic helix-loop-helix protein 33; Hairy-related transcription factor 3; hairy/enhancer-of-split related with YRPW motif 3; Hairy/enhancer-of-split related with YRPW motif-like protein; hes-related family bHLH transcription factor with YRPW motif-like; HEY-like protein; hHeyL; hHRT3; HRT-3

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Gene Aliases: BHLHB33; HESR3; HEY3; HEYL; HRT3

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UniProt ID: (Human) Q9NQ87

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Entrez Gene ID: (Human) 26508

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Function(s)
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific transcription factor activity, protein binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription corepressor activity transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding transcription factor binding microsatellite binding protein homodimerization activity protein heterodimerization activity AF-1 domain binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter outflow tract morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac ventricle morphogenesis transcription from RNA polymerase II promoter Notch signaling pathway mesenchymal cell development glomerulus development skeletal muscle cell differentiation positive regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cardiac epithelial to mesenchymal transition ventricular septum morphogenesis negative regulation of androgen receptor signaling pathway cellular response to BMP stimulus proximal tubule development negative regulation of androgen receptor activity
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