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Invitrogen
HBEGF Polyclonal Antibody
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FIGURE: 1 / 1
HBEGF Antibody (PA5-48083) in WB
Product Details
PA5-48083
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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RRID
Product Specific Information
In direct ELISAs, less than 1% cross-reactivity with recombinant mouse (rm) TREM1, rmTREM2b, and rmTREM3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: diphtheria toxin receptor; hb egf; heparin binding epidermal growth factor-like growth factor; Proheparin-binding EGF-like growth factor
Gene Aliases: AW047313; Dtr; Dts; Hbegf; Hegfl
UniProt ID: (Mouse) Q06186
Entrez Gene ID: (Mouse) 15200
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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