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Invitrogen
HAS3 Polyclonal Antibody
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Product Details
PA5-89266
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Shipping conditions
RRID
Product Specific Information
Immunogen sequence: HRRMRRAGQA LKLPSPRRGS VALCIAAYQE DPDYLRKCLR SAQRISFPDL KVVMVVDGNR QEDAYMLDIF HEVLGGTEQA GFFVWRSNFH EAGEGETEAS LQEGMDRVRD VVRASTFSCI MQKWGGKREV MYTAFKALGD SVDYIQVCDS DTVLDPACTI EMLRVLEEDP QVGGVGGDVQ PPGKGMAVED DQVQAAQVRA TEAWSVHQRH VSREQ; Positive Samples: SKOV3, SW480, Mouse heart, Rat heart, Rat liver; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
HAS1, HAS2 and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins. The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by b-1,3 and b-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, suggesting distinct functional roles of the three proteins. HAS3 produces both secreted and cell-associated forms of hyaluronan and is the most active of the three isoforms of this enzyme in adults. HAS3 gene expression plays a crucial role in the regulation of hyaluronan synthesis in the epidermis. Specifically, IFN-g markedly upregulates HAS3 mRNA, whereas TGFbeta downregulates HAS3 transcript levels. The human HAS3 gene maps to chromosome 16q22. 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: HA synthase 3; Hyaluronan synthase 3; Hyaluronate synthase 3; Hyaluronic acid synthase 3
Gene Aliases: HAS3
UniProt ID: (Human) O00219, (Mouse) O08650
Entrez Gene ID: (Human) 3038, (Mouse) 15118, (Rat) 266805
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