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  • HAND1 Antibodies

OriGene

HAND1 Monoclonal Antibody (OTI1G10), TrueMAB™

View all (11) HAND1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite HAND1 Monoclonal Antibody (OTI1G10), TrueMAB™

  • Antibody Testing Data (5)
HAND1 Antibody in Immunocytochemistry (ICC/IF)
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HAND1 Antibody in Immunocytochemistry (ICC/IF)
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FIGURE: 1 / 5

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HAND1 Antibody (TA502671) in ICC/IF

Anti-HAND1 mouse monoclonal antibody (TA502671) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HAND1(RC200513). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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HAND1 Antibody in Immunocytochemistry (ICC/IF)
HAND1 Antibody in Western Blot (WB)
HAND1 Antibody in Western Blot (WB)
HAND1 Antibody in Flow Cytometry (Flow)
HAND1 Antibody in Flow Cytometry (Flow)
HAND1 Monoclonal Antibody (OTI1G10), TrueMAB™

Product Details

TA502671

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunocytochemistry (ICC/IF)

1:100
-

Flow Cytometry (Flow)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

OTI1G10

Immunogen

Full length human recombinant protein of human HAND1 produced in E.coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.82 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

HAND1 belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHa27; Class A basic helix-loop-helix protein 27; eHAND; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; Heart- and neural crest derivatives-expressed protein 1

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Gene Aliases: BHLHA27; EHAND; HAND1; Hxt; Thing1

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UniProt ID: (Human) O96004

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Entrez Gene ID: (Human) 9421

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription coactivator activity transcription corepressor activity protein binding transcription factor binding enzyme binding identical protein binding protein homodimerization activity bHLH transcription factor binding transcription regulatory region DNA binding protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis mesoderm formation blastocyst development trophectodermal cell differentiation heart looping embryonic heart tube formation cardiac left ventricle formation cardiac right ventricle formation transcription from RNA polymerase II promoter heart development embryonic heart tube development odontogenesis of dentin-containing tooth negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter ventricular cardiac muscle tissue morphogenesis cardiac septum morphogenesis mesenchyme development cartilage morphogenesis trophoblast giant cell differentiation negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
It has to be done as per old AB suggested Products section.
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