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Invitrogen
GRP94 Monoclonal Antibody (9G10), FITC
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FIGURE: 1 / 3
GRP94 Antibody (MA5-45097) in ICC/IF
Product Details
MA5-45097
Species Reactivity
Host/Isotype
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Immunogen
Conjugate
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Product Specific Information
0.5 µg/mL of MA5-45097 was sufficient for detection of Grp94 in 20 µg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-rat IgG:HRP as the secondary antibody.|Detects approximately 98kDa. Does not detect human HSP90, Grp74, or GrpE from E.coli.
Target Information
GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family. It acts as a molecular chaperone that functions in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulates CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, cross-priming, as a potential marker in breast cancer and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. GRP94 is expressed in melanoma or liver metastases of colon carcinoma cells, human gastric carcinoma BGC-823 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250|UniProtKB:P08113}; 98 kDa protein kinase; Endoplasmic reticulum resident protein 99; Endoplasmin; endoplasmin {ECO:0000250|UniProtKB:P08113}; endoplasmin-like protein; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; ERp99; glucose-regulated protein; glucose-regulated protein GRP94; gp96 homolog; GRP-94; GRP94; Heat shock 108 kDa protein; heat shock protein 108; Heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250|UniProtKB:P08113}; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein 90kDa beta, member 1; Heat shock protein family C member 4; heat shock protein gp96; HSP 108; HSP90 beta; hsp90b1 {ECO:0000250|UniProtKB:P08113}; Polymorphic tumor rejection antigen 1; PPK 98; stress-inducible tumor rejection antigen gp96; Transferrin-binding protein; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; Tumor rejection antigen gp96
Gene Aliases: BOS_5572; ECGP; endoplasmin; ERp99; GP96; GRP94; HEL-S-125m; HEL35; hsp108; HSP90B1; HSPC4; ppk98; TA-3; Targ2; Tra-1; TRA1; XELAEV_18017384mg
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