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Invitrogen
GRP94 Monoclonal Antibody (9G10)
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FIGURE: 1 / 18
GRP94 Antibody (MA3-016) in ICC/IF
Product Details
MA3-016
Species Reactivity
Published species
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Product Specific Information
MA3-016 detects glucose regulated protein 94 kDa (GRP94) from human, rat, mouse, chick, hamster and bovine tissues. MA3-016 is also expected to react with GRP94 from Xenopus, human, canine, rabbit, non-human primate, canine, Drosophila, and ovine tissues.
MA3-016 has been successfully used in Western blot, Immunohistochemistry (paraffin), immunocytochemistry, immunofluorescence and immunoprecipitation procedures. By Western blot, this antibody detects an ~108 kDa protein representing GRP94 in chick oviduct cytosol.
The MA3-016 immunogen is chick oviduct GRP94.
Target Information
GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family. It acts as a molecular chaperone that functions in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulates CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, cross-priming, as a potential marker in breast cancer and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. GRP94 is expressed in melanoma or liver metastases of colon carcinoma cells, human gastric carcinoma BGC-823 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250|UniProtKB:P08113}; Endoplasmic reticulum resident protein 99; Endoplasmin; endoplasmin {ECO:0000250|UniProtKB:P08113}; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; ERp99; gp96 homolog; GRP-94; GRP94; Heat shock 108 kDa protein; heat shock protein 108; Heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250|UniProtKB:P08113}; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein 90kDa beta, member 1; Heat shock protein family C member 4; HSP 108; hsp90b1 {ECO:0000250|UniProtKB:P08113}; Polymorphic tumor rejection antigen 1; stress-inducible tumor rejection antigen gp96; Transferrin-binding protein; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; Tumor rejection antigen gp96
Gene Aliases: BOS_5572; ECGP; endoplasmin; ERp99; GP96; GRP94; HEL-S-125m; HEL35; hsp108; HSP90B1; HSPC4; TA-3; Targ2; Tra-1; TRA1
UniProt ID: (Bovine) Q95M18, (Chicken) P08110, (Human) P14625, (Mouse) P08113, (Rat) Q66HD0
Entrez Gene ID: (Bovine) 282646, (Chicken) 374163, (Human) 7184, (Chinese hamster) 100773331, (Mouse) 22027, (Rat) 362862
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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