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Invitrogen
GNE Recombinant Rabbit Monoclonal Antibody (5T9K10)
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FIGURE: 1 / 2
GNE Antibody (MA5-55459) in WB
Product Details
MA5-55459
Species Reactivity
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Product Specific Information
Immunogen Sequence: GALHLIQAAK LGNAKAQSIL RTAGTALGLG VVNILHTMNP SLVILSGVLA SHYIHIVKDV IRQQALSSVQ DVDVVVSDLV DPALLGAASM VLDYTTRRIY
Target Information
GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; N-acylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
Gene Aliases: 2310066H07Rik; DMRV; GLCNE; GNE; IBM2; NM; Uae1
UniProt ID: (Human) Q9Y223, (Rat) O35826, (Mouse) Q91WG8
Entrez Gene ID: (Human) 10020, (Rat) 114711, (Mouse) 50798
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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