Invitrogen

GDNF Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
GDNF Polyclonal Antibody

Product Details

PA5-115279

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human GDNF(Accession P39905), corresponding to amino acid residues P29-P79.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899915

Product Specific Information

Antibody detects endogenous levels of total GDNF.

Target Information

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Astrocyte-derived trophic factor; ATF; Glial cell line-derived neurotrophic factor; H-GDNF; hGDNF; mGDNF; neurotrophic factor

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Gene Aliases: AI385739; ATF1; ATF2; GDNF; HFB1-GDNF; HSCR3

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UniProt ID: (Human) P39905, (Mouse) P48540

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Entrez Gene ID: (Human) 2668, (Mouse) 14573

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Function(s)
Ras guanyl-nucleotide exchange factor activity receptor binding protein binding growth factor activity protein homodimerization activity transforming growth factor beta receptor binding glial cell-derived neurotrophic factor receptor binding
Process(es)
metanephros development ureteric bud development branching involved in ureteric bud morphogenesis neural crest cell migration organ induction postsynaptic membrane organization mesenchymal to epithelial transition involved in metanephros morphogenesis transmembrane receptor protein tyrosine kinase signaling pathway transforming growth factor beta receptor signaling pathway nervous system development peripheral nervous system development cell proliferation positive regulation of cell proliferation response to wounding regulation of gene expression postganglionic parasympathetic fiber development neuron differentiation peristalsis neuron projection development positive regulation of monooxygenase activity negative regulation of neuron apoptotic process positive regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter mRNA stabilization enteric nervous system development sympathetic nervous system development regulation of dopamine uptake involved in synaptic transmission ureteric bud formation regulation of morphogenesis of a branching structure cellular response to dexamethasone stimulus regulation of ureteric bud formation positive regulation of ureteric bud formation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of branching involved in ureteric bud morphogenesis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand MAPK cascade signal transduction adult locomotory behavior positive regulation of dopamine secretion negative regulation of apoptotic process positive regulation of GTPase activity regulation of stem cell differentiation
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