Invitrogen

GATA4 Monoclonal Antibody (7-4)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
GATA4 Monoclonal Antibody (7-4)

Product Details

MA5-42569

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

7-4

Immunogen

Recombinant protein within Mouse GATA4 aa 200-400
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 40% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911710

Product Specific Information

Positive Control: A549 cell lysates, human intestine tissue, human colon carcinoma tissue.

Subcellular Location: Cell nucleus

Target Information

GATA4 is a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in the gene encoding GATA4 have been associated with cardiac septal defects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GAT4; GATA-binding factor 4; GATA-binding protein 4; MGC126629; Transcription factor GATA-4

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Gene Aliases: ASD2; Gata-4; GATA4; TACHD; TOF; VSD1

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UniProt ID: (Human) P43694, (Mouse) Q08369

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Entrez Gene ID: (Human) 2626, (Mouse) 14463

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding transcription factor binding zinc ion binding protein kinase binding activating transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding NFAT protein binding co-SMAD binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding metal ion binding
Process(es)
in utero embryonic development gastrulation with mouth forming second endoderm formation heart looping heart morphogenesis outflow tract morphogenesis atrioventricular valve morphogenesis atrioventricular valve formation mitral valve formation tricuspid valve formation endocardial cushion development cardiac right ventricle morphogenesis ventricular cardiac muscle tissue development cardiac septum development ventricular septum development atrial septum primum morphogenesis atrial septum secundum morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell-cell signaling spermatogenesis heart development male gonad development response to mechanical stimulus regulation of gene expression negative regulation of autophagy positive regulation of vascular endothelial growth factor production cardiac muscle hypertrophy in response to stress signal transduction involved in regulation of gene expression BMP signaling pathway positive regulation of BMP signaling pathway response to retinoic acid embryonic heart tube development embryonic heart tube anterior/posterior pattern specification tube morphogenesis skeletal muscle cell differentiation atrioventricular canal development response to drug response to estrogen positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic digestive tract morphogenesis embryonic morphogenesis embryonic foregut morphogenesis cardiac muscle tissue development cardiac muscle cell differentiation Sertoli cell differentiation regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation canonical Wnt signaling pathway transdifferentiation SMAD protein signal transduction atrial septum morphogenesis lung morphogenesis lung lobe formation diaphragm morphogenesis intestinal epithelial cell differentiation vasculogenesis involved in coronary vascular morphogenesis cell growth involved in cardiac muscle cell development cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus epithelial cell fate commitment seminiferous tubule development regulation of cardiac muscle cell contraction cardiac ventricle morphogenesis endoderm development blood coagulation response to vitamin A cell fate commitment cell development anatomical structure formation involved in morphogenesis positive regulation of cardioblast differentiation cellular response to glucose stimulus
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