Bioss

G protein alphaisoforms XLas Polyclonal Antibody

View all (40) GNAS antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

BS-8160R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human G protein alpha isoforms XLas, amino acids 701-800.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adenylate cyclase-stimulating G alpha protein; Alternative gene product encoded by XL-exon; dJ309F20.1.1; dJ806M20.3.3; Extra large alphas protein; G protein subunit alpha S; G-alpha-8; GNAS; GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; gnas {ECO:0000312|RGD:2716}; Gs alpha subunit; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide binding protein alpha s; guanine nucleotide regulatory protein; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide-binding protein G-s, alpha subunit; MGC33735; NESP55; neuroendocrine secretory protein; Neuroendocrine secretory protein 55; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; PHP1C; Protein ALEX; RP4-543J19.4; secretogranin VI; stimulatory G-protein alpha subunit; XLalphas; XLas

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Gene Aliases: 5530400H20Rik; A930027G11Rik; AHO; C130027O20Rik; C20orf45; Galphas; GNAS; GNAS1; Gnasxl; Gnpas; GPSA; GSA; GSP; MNCb-5546; NESP; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; SCG6; SgVI

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UniProt ID: (Human) P84996, (Mouse) Q6R0H6, (Rat) P63095

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Entrez Gene ID: (Human) 2778, (Mouse) 14683, (Rat) 24896

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Function(s)
GTPase activity signal transducer activity insulin-like growth factor receptor binding protein binding GTP binding G-protein beta/gamma-subunit complex binding beta-2 adrenergic receptor binding D1 dopamine receptor binding mu-type opioid receptor binding ionotropic glutamate receptor binding metal ion binding corticotropin-releasing hormone receptor 1 binding nucleotide binding G-protein alpha-subunit binding guanyl nucleotide binding protein domain specific binding G-protein beta-subunit binding alpha-tubulin binding
Process(es)
skeletal system development tissue homeostasis positive regulation of protein phosphorylation endochondral ossification energy reserve metabolic process DNA methylation regulation of transcription from RNA polymerase II promoter signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway sensory perception of chemical stimulus post-embryonic development regulation of signal transduction positive regulation of sodium ion transport positive regulation of cAMP biosynthetic process embryonic hindlimb morphogenesis multicellular organism growth negative regulation of renal sodium excretion negative regulation of multicellular organism growth post-embryonic body morphogenesis response to drug positive regulation of GTPase activity skin development positive regulation of cAMP-mediated signaling positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation negative regulation of blood pressure developmental growth embryonic cranial skeleton morphogenesis cognition cartilage development calcium ion homeostasis bone development hair follicle placode formation platelet aggregation response to parathyroid hormone cellular response to prostaglandin E stimulus genetic imprinting cellular response to catecholamine stimulus adenylate cyclase-activating adrenergic receptor signaling pathway regulation of parathyroid hormone secretion metabolic process
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