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Fibroblast Activation Protein Alpha/FAP-1 Monoclonal Antibody (FAP/4851)

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Datasheet
Protocols
Questions & Answers

Cite Fibroblast Activation Protein Alpha/FAP-1 Monoclonal Antibody (FAP/4851)

  • Antibody Testing Data (3)
Fibroblast Activation Protein Alpha/FAP-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Fibroblast Activation Protein Alpha/FAP-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Fibroblast Activation Protein Alpha/FAP-1 Antibody (2191-MSM1-P1ABX) in IHC (P)

Formalin-fixed, paraffin-embedded human placenta stained with Fibroblast Activation Protein Mouse Monoclonal Antibody (FAP/4851). Inset: PBS instead of primary antibody, secondary only negative control. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Fibroblast Activation Protein Alpha/FAP-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Fibroblast Activation Protein Alpha/FAP-1 Antibody in Peptide array (ARRAY)
Fibroblast Activation Protein Alpha/FAP-1 Antibody in SDS-PAGE (SDS-PAGE)
Fibroblast Activation Protein Alpha/FAP-1 Monoclonal Antibody (FAP/4851)

Product Details

2191-MSM1-P1ABX

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1-2 µg/mL
-

Peptide Array (Array)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2c, kappa

Class

Monoclonal

Type

Antibody

Clone

FAP/4851

Immunogen

Recombinant fragment (around aa 1-200) of human FAP protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; FAPalpha; Fibroblast activation protein alpha; fibroblast activation protein, alpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Prolyl endopeptidase FAP; Seprase; Serine integral membrane protease; SIMP; Surface-expressed protease

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Gene Aliases: DPPIV; FAP; FAPA; SIMP

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UniProt ID: (Human) Q12884

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Entrez Gene ID: (Human) 2191

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Function(s)
protease binding endopeptidase activity metalloendopeptidase activity serine-type endopeptidase activity integrin binding protein binding peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity protein homodimerization activity protein dimerization activity
Process(es)
angiogenesis proteolysis cell adhesion regulation of collagen catabolic process negative regulation of extracellular matrix disassembly endothelial cell migration proteolysis involved in cellular protein catabolic process regulation of fibrinolysis negative regulation of cell proliferation involved in contact inhibition positive regulation of cell cycle arrest mitotic cell cycle arrest melanocyte proliferation positive regulation of execution phase of apoptosis melanocyte apoptotic process negative regulation of extracellular matrix organization
It has to be done as per old AB suggested Products section.
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