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Invitrogen
FZD4 Monoclonal Antibody (145901)
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Product Details
MA5-23923
Species Reactivity
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Type
Clone
Immunogen
Conjugate
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RRID
Product Specific Information
In Western blots, no cross-reactivity with recombinant mouse (rm) Frizzled-1, -2, -3, -6, -7, -8, or recombinant human Frizzled-5 is observed. This antibody detects Frizzled-4 by flow cytometry and immunohistochemistry on mouse differentiated embryoid bodies derived from the mouse embryonic cell line, D3.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
FZD4 is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Frizzled 4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CD344; CD344 antigen; frizzled 4, seven transmembrane spanning receptor; frizzled family receptor 4; frizzled homolog 4; Frizzled-4; Fz-4; FzE4; mFz4; MGC34390; WNT receptor frizzled-4
Gene Aliases: CD344; EVR1; FEVR; Fz-4; Fz4; FZD4; FZD4S; FzE4; GPCR; hFz4
UniProt ID: (Human) Q9ULV1, (Mouse) Q61088
Entrez Gene ID: (Human) 8322, (Mouse) 14366
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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