Invitrogen

FSHR Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
FSHR Polyclonal Antibody

Product Details

PA5-99424

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Affinity Purification (AP)

-
- -
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FSHR(Accession P23945), corresponding to amino acid residues H215-M265.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818357

Product Specific Information

Antibody detects endogenous levels of total FSHR.

Target Information

Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R

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Gene Aliases: FSHR; FSHR1; FSHRO; LGR1; ODG1

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UniProt ID: (Human) P23945, (Rat) P20395, (Mouse) P35378

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Entrez Gene ID: (Human) 2492, (Rat) 25449, (Mouse) 14309

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Function(s)
follicle-stimulating hormone receptor activity protein binding G-protein coupled peptide receptor activity G-protein coupled receptor activity peptide hormone binding signal transducer activity protein-hormone receptor activity
Process(es)
ovarian follicle development primary ovarian follicle growth regulation of protein phosphorylation regulation of systemic arterial blood pressure adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway spermatogenesis spermatid development locomotory behavior male gonad development cellular water homeostasis regulation of platelet-derived growth factor receptor signaling pathway ovulation cycle process neuron projection development regulation of hormone metabolic process regulation of chromosome organization regulation of intracellular estrogen receptor signaling pathway positive regulation of intracellular estrogen receptor signaling pathway sperm chromatin condensation spermatogenesis, exchange of chromosomal proteins follicle-stimulating hormone signaling pathway regulation of MAPK cascade transcytosis regulation of osteoclast differentiation negative regulation of bone resorption Sertoli cell development Sertoli cell proliferation uterus development regulation of acetylcholine metabolic process basement membrane organization signal transduction G-protein coupled receptor signaling pathway activation of adenylate cyclase activity female gonad development hormone-mediated signaling pathway female gamete generation gonad development regulation of protein kinase A signaling positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of ERK1 and ERK2 cascade
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