OriGene

FOXC2 Monoclonal Antibody (OTI3E3), TrueMAB™

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Datasheet
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Questions & Answers
Datasheet
Protocols
Questions & Answers
FOXC2 Monoclonal Antibody (OTI3E3), TrueMAB™

Product Details

CF807700

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI3E3

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-280 of human FOXC2 produced in E.coli.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

Forkhead box protein C2 (FOXC2) is a transciptional activator and is characterized by a distinct DNA-binding forkhead domain. FOXC2 may be involved in the formation of special mesenchymal tissues. Mutations affecting the gene can cause lymphedema-distichiasis (LYD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: forkhead box C2 (MFH-1, mesenchyme forkhead 1); Forkhead box protein C2; forkhead, Drosophila, homolog-like 14; Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; mesenchyme forkhead 1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; Transcription factor FKH-14

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Gene Aliases: FKHL14; FOXC2; LD; MFH-1; MFH1

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UniProt ID: (Human) Q99958

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Entrez Gene ID: (Human) 2303

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Function(s)
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding chromatin DNA binding identical protein binding sequence-specific DNA binding transcription regulatory region DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ossification patterning of blood vessels metanephros development ureteric bud development somitogenesis lymphangiogenesis blood vessel remodeling transcription from RNA polymerase II promoter Notch signaling pathway mesoderm development heart development insulin receptor signaling pathway response to hormone positive regulation of endothelial cell migration neural crest cell development collagen fibril organization positive regulation of cell adhesion mediated by integrin embryonic heart tube development positive regulation of vascular wound healing camera-type eye development positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of organ growth vascular endothelial growth factor receptor signaling pathway paraxial mesodermal cell fate commitment embryonic viscerocranium morphogenesis artery morphogenesis regulation of blood vessel size ventricular cardiac muscle tissue morphogenesis cardiac muscle cell proliferation glomerular endothelium development glomerular visceral epithelial cell differentiation glomerular mesangial cell development positive regulation of cell migration involved in sprouting angiogenesis negative regulation of apoptotic process involved in outflow tract morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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