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FOXC2 Monoclonal Antibody (3H5)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
FOXC2 Monoclonal Antibody (3H5)

Product Details

H00002303-M05

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

ELISA (ELISA)

3 ng/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

3H5

Immunogen

FOXC2 (NP_005242, 156 a.a. approximately 256 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: FENGSFLRRR RRFKKKDVSK EKEERAHLKE PPPAASKGAP ATPHLADAPK EAEKKVVIKS EAASPALPVI TKVETLSPES ALQGSPRSAA STPAGSPDGS L

Target Information

Forkhead box protein C2 (FOXC2) is a transciptional activator and is characterized by a distinct DNA-binding forkhead domain. FOXC2 may be involved in the formation of special mesenchymal tissues. Mutations affecting the gene can cause lymphedema-distichiasis (LYD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BF-3; Brain factor 3; forkhead box C2 (MFH-1 mesenchyme forkhead 1); forkhead box C2 (MFH-1, mesenchyme forkhead 1); Forkhead box protein C2; forkhead, Drosophila, homolog-like 14; Forkhead-related protein FKHL14; HFH-BF-3; Mesenchyme fork head protein 1; mesenchyme forkhead 1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; Transcription factor FKH-14

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Gene Aliases: Fkh14; FKHL14; FOXC2; Hfhbf3; LD; MFH-1; MFH1

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UniProt ID: (Human) Q99958, (Rat) Q63246

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Entrez Gene ID: (Human) 2303, (Rat) 171356

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Function(s)
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding chromatin DNA binding identical protein binding sequence-specific DNA binding transcription regulatory region DNA binding DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development ossification blood vessel development patterning of blood vessels metanephros development ureteric bud development somitogenesis kidney development lymph vessel development lymphangiogenesis blood vessel remodeling heart morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter Notch signaling pathway heart development cell proliferation insulin receptor signaling pathway response to hormone positive regulation of endothelial cell migration neural crest cell development collagen fibril organization positive regulation of cell adhesion mediated by integrin embryonic heart tube development positive regulation of vascular wound healing camera-type eye development positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of organ growth vascular endothelial growth factor receptor signaling pathway paraxial mesoderm formation paraxial mesodermal cell fate commitment embryonic cranial skeleton morphogenesis embryonic viscerocranium morphogenesis embryonic skeletal system morphogenesis artery morphogenesis regulation of blood vessel size ventricular cardiac muscle tissue morphogenesis cardiac muscle cell proliferation glomerular endothelium development glomerular visceral epithelial cell differentiation glomerular mesangial cell development positive regulation of cell migration involved in sprouting angiogenesis negative regulation of apoptotic process involved in outflow tract morphogenesis mesoderm development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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