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Abnova
FLT4 Monoclonal Antibody (5F11)
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Product Details
H00002324-M02
Species Reactivity
Host/Isotype
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Type
Clone
Immunogen
Conjugate
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Purification
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Product Specific Information
Sequence of this protein is as follows: ITEESHVIDT GDSLSISCRG QHPLEWAWPG AQEAPATGDK DSEDTGVVRD CEGTDARPYC KVLLLHEVHA NDTGSYVCYY KYIKARIEGT TAASSYVFVR
Target Information
Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: FLT-4; Fms-like tyrosine kinase 4; fms-related tyrosine kinase 4; soluble VEGFR 3; sVEGFR 3; Tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; VEGF R3; VEGFR-3
Gene Aliases: FLT-4; FLT4; FLT41; LMPH1A; PCL; VEGFR-3; VEGFR3
UniProt ID: (Human) P35916
Entrez Gene ID: (Human) 2324
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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