Abnova

FGF8 Monoclonal Antibody (2A10)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
FGF8 Monoclonal Antibody (2A10)

Product Details

H00002253-M01

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

ELISA (ELISA)

0.3 ng/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

2A10

Immunogen

FGF8 (NP_149354, 65 a.a. approximately 133 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: SRRLIRTYQL YSRTSGKHVQ VLANKRINAM AEDGDPFAKL IVETDTFGSR VRVRGAETGL YICMNKKGK

Target Information

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIGF; androgen-induced; Androgen-induced growth factor; FGF; FGF-8; Fibroblast growth factor; Fibroblast growth factor 8; fibroblast growth factor 8 (androgen-induced); HBGF-8; Heparin-binding growth factor 8; MGC149376

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Gene Aliases: AIGF; FGF-8; FGF8; HBGF-8; HH6; KAL6

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UniProt ID: (Human) P55075, (Mouse) P37237

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Entrez Gene ID: (Human) 2253, (Rat) 29349, (Mouse) 14179

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Function(s)
protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity fibroblast growth factor receptor binding growth factor activity 1-phosphatidylinositol-3-kinase activity chemoattractant activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity type 1 fibroblast growth factor receptor binding type 2 fibroblast growth factor receptor binding receptor binding
Process(es)
MAPK cascade patterning of blood vessels metanephros development branching involved in ureteric bud morphogenesis organ induction kidney development mesonephros development neural plate morphogenesis heart looping blood vessel remodeling heart morphogenesis outflow tract septum morphogenesis outflow tract morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation apoptotic process response to oxidative stress determination of left/right symmetry heart development motor neuron axon guidance mesodermal cell migration positive regulation of cell proliferation gonad development fibroblast growth factor receptor signaling pathway embryo development ending in birth or egg hatching positive regulation of gene expression response to organic cyclic compound telencephalon development pallium development subpallium development forebrain dorsal/ventral pattern formation cell proliferation in forebrain forebrain neuron development central nervous system neuron development signal transduction involved in regulation of gene expression lung development BMP signaling pathway male genitalia development thyroid gland development otic vesicle formation midbrain-hindbrain boundary development dorsal/ventral axon guidance embryonic heart tube development limb morphogenesis embryonic hindlimb morphogenesis aorta morphogenesis inner ear morphogenesis odontogenesis regulation of odontogenesis of dentin-containing tooth response to drug negative regulation of apoptotic process negative regulation of neuron apoptotic process cell fate commitment positive regulation of mitotic nuclear division positive regulation of organ growth generation of neurons forebrain morphogenesis positive chemotaxis negative regulation of cardiac muscle tissue development pharyngeal system development canonical Wnt signaling pathway corticotropin hormone secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation bone development lung morphogenesis branching involved in salivary gland morphogenesis neuroepithelial cell differentiation dopaminergic neuron differentiation cell migration involved in mesendoderm migration multicellular organism development cell differentiation positive regulation of cell division gastrulation anatomical structure morphogenesis regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process positive regulation of GTPase activity phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling positive regulation of ERK1 and ERK2 cascade
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