Invitrogen

Ezrin Recombinant Rabbit Monoclonal Antibody (1L5O2)

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Datasheet
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Datasheet
Protocols
Questions & Answers
Ezrin Recombinant Rabbit Monoclonal Antibody (1L5O2)

Product Details

MA5-35229

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

1L5O2

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Ezrin (P15311)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.73 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849133

Product Specific Information

Immunogen sequence: IEVQQMKAQA REEKHQKQLE RQQLETEKKR RETVEREKEQ MMREKEELML RLQDYEEKTK KAERELSEQI QRALQLEEER KRAQEEAERL EADRMAALRA K

Target Information

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cytovillin; cytovillin 2; DKFZp762H157; epididymis secretory protein Li 105; EZRI; Ezrin; FLJ26216; MGC1584; p81; villin 2 (ezrin); Villin-2

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Gene Aliases: CVIL; CVL; EZR; HEL-S-105; VIL2

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UniProt ID: (Human) P15311

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Entrez Gene ID: (Human) 7430

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Function(s)
actin binding protein binding microtubule binding protein domain specific binding protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding S100 protein binding poly(A) RNA binding cell adhesion molecule binding actin filament binding ATPase binding cadherin binding involved in cell-cell adhesion
Process(es)
negative regulation of transcription from RNA polymerase II promoter intestinal D-glucose absorption sphingosine-1-phosphate signaling pathway cytoskeletal anchoring at plasma membrane leukocyte cell-cell adhesion axon guidance regulation of cell shape regulation of cell size positive regulation of gene expression protein kinase A signaling gland morphogenesis membrane to membrane docking microvillus assembly astral microtubule organization actin cytoskeleton reorganization receptor internalization regulation of microvillus length regulation of actin cytoskeleton organization cellular protein complex localization positive regulation of multicellular organism growth cortical microtubule organization establishment of epithelial cell apical/basal polarity filopodium assembly phosphatidylinositol-mediated signaling positive regulation of protein secretion negative regulation of T cell receptor signaling pathway actin filament bundle assembly establishment of centrosome localization establishment of endothelial barrier negative regulation of ERK1 and ERK2 cascade cellular response to cAMP protein localization to cell cortex establishment of protein localization to plasma membrane positive regulation of establishment of protein localization to plasma membrane negative regulation of interleukin-2 secretion regulation of NIK/NF-kappaB signaling regulation of organelle assembly terminal web assembly positive regulation of protein localization to early endosome positive regulation of cellular protein catabolic process negative regulation of p38MAPK cascade positive regulation of early endosome to late endosome transport
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