Invitrogen

Epo Polyclonal Antibody

1 Reference
View all (38) Epo antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Epo Polyclonal Antibody

Product Details

PA5-77965

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000-1:20,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

ELISA (ELISA)

1:1,000-1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Full length human EPO recombinant protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735764

Product Specific Information

Positive Control: Recombinant human EPO protein

Predicted Reactivity: Mouse (80%), Dog (81%), Rabbit (81%), Rhesus Monkey (90%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: epoetin; Erythropoietin; MGC138142

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Gene Aliases: EP; EPO; MVCD2

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UniProt ID: (Human) P01588, (Mouse) P07321, (Rat) P29676

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Entrez Gene ID: (Human) 2056, (Mouse) 13856, (Rat) 24335

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Function(s)
erythropoietin receptor binding hormone activity protein binding protein kinase activator activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter apoptotic process acute-phase response signal transduction embryo implantation aging blood circulation positive regulation of cell proliferation response to salt stress negative regulation of calcium ion transport into cytosol positive regulation of neuron projection development peptidyl-serine phosphorylation erythrocyte differentiation activation of protein kinase activity response to lipopolysaccharide response to vitamin A response to testosterone positive regulation of activated T cell proliferation positive regulation of tyrosine phosphorylation of Stat5 protein hemoglobin biosynthetic process erythrocyte maturation response to estrogen positive regulation of DNA replication positive regulation of transcription, DNA-templated positive regulation of Ras protein signal transduction response to axon injury response to electrical stimulus response to hyperoxia regulation of transcription from RNA polymerase II promoter in response to hypoxia positive regulation of ERK1 and ERK2 cascade response to interleukin-1 cellular hyperosmotic response negative regulation of neuron death negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress negative regulation of erythrocyte apoptotic process negative regulation of cation channel activity angiogenesis response to hypoxia heart morphogenesis regulation of transcription from RNA polymerase II promoter negative regulation of myeloid cell apoptotic process negative regulation of apoptotic process positive regulation of neuron differentiation positive regulation of protein kinase activity cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue morphogenesis vasculogenesis involved in coronary vascular morphogenesis visceral serous pericardium development response to nutrient
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