Invitrogen

Epiregulin Polyclonal Antibody

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View all (8) Epiregulin antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
Epiregulin Polyclonal Antibody

Product Details

PA5-46969

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1 µg/mL
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

ELISA (ELISA)

Assay-Dependent
-

Neutralization (Neu)

0.3-1.5 µg/mL
-
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived recombinant human Epiregulin Val63-Leu108
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2610406

Product Specific Information

In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant mouse Epiregulin is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Proepiregulin

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Gene Aliases: Ep; EPR; ER; EREG

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UniProt ID: (Human) O14944

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Entrez Gene ID: (Human) 2069

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Function(s)
protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding protein binding growth factor activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Process(es)
MAPK cascade angiogenesis ovarian cumulus expansion oocyte maturation positive regulation of cytokine production female meiotic division epidermal growth factor receptor signaling pathway cell-cell signaling positive regulation of cell proliferation negative regulation of cell proliferation mRNA transcription anatomical structure morphogenesis organ morphogenesis regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway keratinocyte differentiation ovulation ERBB2 signaling pathway wound healing positive regulation of cytokine biosynthetic process positive regulation of phosphorylation luteinizing hormone signaling pathway response to peptide hormone positive regulation of GTPase activity keratinocyte proliferation positive regulation of innate immune response positive regulation of interleukin-6 biosynthetic process positive regulation of DNA replication positive regulation of epidermal growth factor-activated receptor activity positive regulation of mitotic nuclear division positive regulation of protein kinase activity negative regulation of transcription, DNA-templated phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling positive regulation of fibroblast proliferation primary follicle stage positive regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation negative regulation of smooth muscle cell differentiation positive regulation of cell division regulation of cell motility
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