Invitrogen

EphA2 Recombinant Rabbit Monoclonal Antibody (301)

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Datasheet
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Datasheet
Protocols
Questions & Answers
EphA2 Recombinant Rabbit Monoclonal Antibody (301)

Product Details

MA5-29699

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

1:25-1:100
-

ELISA (ELISA)

1:5,000-1:10,000
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

301

Immunogen

Recombinant Mouse EphA2 protein (Met1-Asn535)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2785523

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This antibody has specificity for Mouse EphA2.

Target Information

EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2

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Gene Aliases: AW545284; Eck; Epha2; Myk2; Sek-2; Sek2

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UniProt ID: (Mouse) Q03145

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Entrez Gene ID: (Mouse) 13836

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
skeletal system development angiogenesis blood vessel development vasculogenesis osteoblast differentiation protein phosphorylation apoptotic process cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage regulation of lamellipodium assembly notochord formation phosphorylation cell migration peptidyl-tyrosine phosphorylation neural tube development cell differentiation neuron differentiation keratinocyte differentiation osteoclast differentiation mammary gland epithelial cell proliferation regulation of cell adhesion mediated by integrin post-anal tail morphogenesis protein kinase B signaling regulation of blood vessel endothelial cell migration regulation of angiogenesis bone remodeling ephrin receptor signaling pathway axial mesoderm formation notochord morphogenesis negative regulation of protein kinase B signaling notochord cell development cell chemotaxis branching involved in mammary gland duct morphogenesis lens fiber cell morphogenesis regulation of ERK1 and ERK2 cascade response to growth factor positive regulation of establishment of protein localization to plasma membrane activation of GTPase activity
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