Invitrogen

EphA2 Monoclonal Antibody (1B3C7)

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View all (44) EphA2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-15284

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Flow Cytometry (Flow)

-
View 1 publication 1 publication

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Mouse / IgM

Class

Monoclonal

Type

Antibody

Clone

1B3C7

Immunogen

Purified recombinant fragment of EphA2 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10978916

Product Specific Information

MA5-15284 targets EphA2 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.

The MA5-15284 immunogen is purified recombinant fragment of EphA2 expressed in E. Coli.

Target Information

EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; soluble EPHA2 variant 1; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2

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Gene Aliases: ARCC2; AW545284; CTPA; CTPP1; CTRCT6; ECK; EPHA2; Myk2; Sek-2; Sek2

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UniProt ID: (Human) P29317, (Mouse) Q03145

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Entrez Gene ID: (Human) 1969, (Mouse) 13836

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Function(s)
transmembrane receptor protein tyrosine kinase activity ephrin receptor activity protein binding ATP binding cadherin binding involved in cell-cell adhesion nucleotide binding protein kinase activity protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
skeletal system development angiogenesis blood vessel development vasculogenesis osteoblast differentiation protein phosphorylation apoptotic process cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage regulation of lamellipodium assembly notochord formation phosphorylation cell migration peptidyl-tyrosine phosphorylation neural tube development cell differentiation neuron differentiation keratinocyte differentiation osteoclast differentiation mammary gland epithelial cell proliferation regulation of cell adhesion mediated by integrin post-anal tail morphogenesis protein kinase B signaling regulation of blood vessel endothelial cell migration regulation of angiogenesis bone remodeling ephrin receptor signaling pathway axial mesoderm formation notochord morphogenesis negative regulation of protein kinase B signaling notochord cell development cell chemotaxis branching involved in mammary gland duct morphogenesis lens fiber cell morphogenesis regulation of ERK1 and ERK2 cascade response to growth factor positive regulation of establishment of protein localization to plasma membrane activation of GTPase activity multicellular organism development viral process cell-cell adhesion
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