Bethyl Laboratories

EZH2 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

A304-197A

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunoprecipitation (IP)

2-10 µg/mg lysate
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 696 to 746 of human Enhancer of Zeste Homolog 2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

phosphate/tris citrate, pH 7-8

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Based on 100% sequence identity, this antibody is predicted to react with Zebrafish, X. laevis and X. tropicalis

Target Information

EZH2 (Histone-lysine N-methyltransferase) is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Mutations affecting EZH2 can cause Weaver syndrome (WVS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: an; Enhancer of zeste homolog 2; ENX 1; ENX-1; EZH 2; EZH-2; Histone-lysine N-methyltransferase EZH2; Lysine N-methyltransferase 6; OTTHUMP00000213774; OTTHUMP00000213778; OTTHUMP00000213779; OTTHUMP00000213780

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Gene Aliases: ENX-1; ENX1; Enx1h; EZH1; EZH2; EZH2b; KMT6; KMT6A; mKIAA4065; WVS; WVS2

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UniProt ID: (Human) Q15910, (Mouse) Q61188

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Entrez Gene ID: (Human) 2146, (Mouse) 14056

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Function(s)
core promoter binding DNA binding chromatin binding RNA binding protein binding protein-lysine N-methyltransferase activity histone-lysine N-methyltransferase activity chromatin DNA binding histone methyltransferase activity ribonucleoprotein complex binding sequence-specific DNA binding histone methyltransferase activity (H3-K27 specific) promoter-specific chromatin binding regulatory region DNA binding methyltransferase activity transferase activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter DNA methylation chromatin organization transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of epithelial to mesenchymal transition regulation of gliogenesis skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration cerebellar cortex development hippocampus development response to estradiol negative regulation of transcription elongation from RNA polymerase II promoter regulation of cell proliferation regulation of circadian rhythm positive regulation of MAP kinase activity negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of GTPase activity negative regulation of epidermal cell differentiation negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated negative regulation of retinoic acid receptor signaling pathway rhythmic process negative regulation of striated muscle cell differentiation cellular response to hydrogen peroxide G1 to G0 transition histone H3-K27 methylation protein localization to chromatin positive regulation of protein serine/threonine kinase activity positive regulation of dendrite development negative regulation of G1/S transition of mitotic cell cycle regulation of protein phosphorylation regulation of transcription from RNA polymerase II promoter regulation of gene expression negative regulation of gene expression chromatin modification histone methylation peptidyl-lysine methylation methylation regulation of neurogenesis
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