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Proteintech
EXOSC7 Polyclonal Antibody
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Product Details
25292-1-AP
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MASVTLSEA EKVYIVHGVQ EDLRVDGRGC EDYRCVEVET DVVSNTSGSA RVKLGHTDIL VGVKAEMGTP KLEKPNEGYL EFFVDCSASA TPEFEGRGGD DLGTEIANTL YRIFNNKSSV DLKTLCISPR EHCWVLYVDV LLLECGGNLF DAISIAVKAA LFNTRIPRVR VLEDEEGSKD IELSDDPYDC IRLSVENVPC IVTLCKIGYR HVVDATLQEE ACSLASLLVS VTSKGVVTCM RKVGKGSLDP ESIFEMMETG KRVGKVLHAS LQSVLHKEES LGPKRQKVGF LG (1-291 aa encoded by BC012831)
Target Information
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Exosome complex component RRP42; Exosome complex exonuclease RRP42; Exosome component 7; p8; Ribosomal RNA-processing protein 42
Gene Aliases: 2610002K22Rik; AV212732; EAP1; EXOSC7; hRrp42p; KIAA0116; mKIAA0116; p8; RRP42; Rrp42p
UniProt ID: (Human) Q15024, (Mouse) Q9D0M0
Entrez Gene ID: (Human) 23016, (Mouse) 66446
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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