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Abnova
EXDL2 Polyclonal Antibody, MaxPab™
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Product Details
H00055218-B01P
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MASPSGLCVL VRLPKLICGG KTLPRTLLDI LADGTILKVG VGCSEDASKL LQDYGLVVRG CLDLRYLAMR QRNNLLCNGL SLKSLAETVL NFPLDKSLLL RCSNWDAETL TEDQVIYAAR DAQISVALFL HLLGYPFSRN SPGEKNDDHS SWRKVLEKCQ GVVDIPFRSK GMSRLGEEVN GEATESQQKP RNKKSKMDGM VPGNHQGRDP RKHKRKPLGV GYSARKSPLY DNCFLHAPDG QPLCTCDRRK AQWYLDKGIG ELVSEEPFVV KLRFEPAGRP ESPGDYYLMV KENLCVVCGK RDSYIRKNVI PHEYRKHFPI EMKDHNSHDV LLLCTSCHAI SNYYDNHLKQ QLAKEFQAPI GSEEGLRLLE DPERRQVRSG ARALLNAESL PTQRKEELLQ ALREFYNTDV VTEEMLQEAA SLETRISNEN YVPHGLKVVQ CHSQGGLRSL MQLESRWRQH FLDSMQPKHL PQQWSVDHNH QKLLRKFGED LPIQLS
Target Information
Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 3'-5' exoribonuclease EXD2; Exonuclease 3'-5' domain-containing protein 2; exonuclease 3'-5' domain-like 2; Exonuclease 3'-5' domain-like-containing protein 2
Gene Aliases: C14orf114; EXD2; EXDL2
UniProt ID: (Human) Q9NVH0
Entrez Gene ID: (Human) 55218
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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