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  • Primary Antibodies ›
  • Endothelin 2 Antibodies

Bioss

ET-2/Endothelin 2 Polyclonal Antibody

View all (6) Endothelin 2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite ET-2/Endothelin 2 Polyclonal Antibody

ET-2/Endothelin 2 Polyclonal Antibody

Product Details

BS-11280R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Cat, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Endolin 2, amino acids 49-59.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Endothelins are endothelium-derived vasoconstrictor peptides. Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene. The secreted peptide (~2kD, 21 amino acids) is produced as a result of endothelin-2 precursor (~20 kD) processing and functions as a ligand for endothelin receptors which upon peptide binding modulates a wide array of cell signaling events. Diseases associated with endothelins include aortic disease and patent ductus arteriosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EDN 2; EDN-2; Endothelin isopeptide 2; Endothelin-2; ET-2; PP ET-2; PPET2; preproendothelin 2; Preproendothelin-2; RNEDN2S01; Vasoactive intestinal contractor; vasoactive intestinal contractor peptide; VIC

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Gene Aliases: EDN2; ET-2; ET2; PPET2; VIC

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UniProt ID: (Human) P20800, (Cat) Q5NRQ0, (Mouse) P22389

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Entrez Gene ID: (Human) 1907, (Cat) 494215, (Rat) 24324, (Mouse) 13615

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Function(s)
hormone activity endothelin B receptor binding
Process(es)
prostaglandin biosynthetic process ovarian follicle rupture temperature homeostasis positive regulation of leukocyte chemotaxis regulation of systemic arterial blood pressure by endothelin positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway regulation of blood pressure positive regulation of cell proliferation positive regulation of heart rate artery smooth muscle contraction vein smooth muscle contraction cytokine-mediated signaling pathway regulation of vasoconstriction calcium-mediated signaling neutrophil chemotaxis macrophage activation vasoconstriction positive regulation of smooth muscle contraction positive regulation of hormone secretion negative regulation of hormone secretion inositol phosphate-mediated signaling macrophage chemotaxis lung alveolus development positive regulation of prostaglandin-endoperoxide synthase activity energy homeostasis hormonal regulation of the force of heart contraction positive regulation of the force of heart contraction by chemical signal cell surface receptor signaling pathway regulation of blood vessel size
It has to be done as per old AB suggested Products section.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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