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Invitrogen
ERCC1 Polyclonal Antibody
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FIGURE: 1 / 8
ERCC1 Antibody (PA5-77971) in ICC/IF
Product Details
PA5-77971
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Positive Control: 293T, A431, HeLa, HepG2, PC-12, Rat2
Predicted Reactivity: Mouse (86%), Pig (87%), Chimpanzee (100%), Bovine (87%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It is responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). It participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. (Uniprot)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: DNA excision repair protein ERCC-1; excision repair cross-complementation group 1; excision repair cross-complementing 1; excision repair cross-complementing rodent repair deficiency, complementation group 1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
Gene Aliases: COFS4; ERCC1; RAD10; UV20
UniProt ID: (Human) P07992
Entrez Gene ID: (Human) 2067, (Rat) 292673
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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