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  • Primary Antibodies ›
  • ENPP1 Antibodies

Invitrogen

ENPP1 Polyclonal Antibody

View all (9) ENPP1 antibodies

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Datasheet
Protocols
Questions & Answers

Cite ENPP1 Polyclonal Antibody

  • Antibody Testing Data (4)
ENPP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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ENPP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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ENPP1 Antibody (PA5-18429) in IHC (P)

Immunohistochemistry analysis of ENPP1 in human pancreas. Samples were incubated with ENPP1 polyclonal antibody (Product # PA5-18429) using a dilution of 5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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ENPP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
ENPP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
ENPP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
ENPP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
ENPP1 Polyclonal Antibody

Product Details

PA5-18429

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-4 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (KTHLPTFSQED) corresponding to the C-terminus amino acids of ENPP1 (aa 915-925).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11000624

Product Specific Information

This antibody is predicted to react with mouse and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

Target Information

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alkaline phosphodiesterase 1; Alkaline phosphodiesterase I; E-NPP 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; HGNC:3356; Ly-41 antigen; Membrane component chromosome 6 surface marker 1; membrane component, chromosome 6, surface marker 1; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTHUMP00000043194; Phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein 1; Plasma-cell membrane glycoprotein PC-1

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Gene Aliases: ARHR2; COLED; ENPP1; M6S1; NPP1; NPPS; PC-1; PC1; PCA1; PDNP1

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UniProt ID: (Human) P22413

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Entrez Gene ID: (Human) 5167

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Function(s)
nucleic acid binding phosphodiesterase I activity nucleotide diphosphatase activity scavenger receptor activity insulin receptor binding calcium ion binding protein binding ATP binding zinc ion binding polysaccharide binding NADH pyrophosphatase activity protein homodimerization activity nucleoside-triphosphate diphosphatase activity 3'-phosphoadenosine 5'-phosphosulfate binding
Process(es)
generation of precursor metabolites and energy riboflavin metabolic process phosphate-containing compound metabolic process receptor-mediated endocytosis immune response nucleoside triphosphate catabolic process negative regulation of cell growth regulation of bone mineralization inorganic diphosphate transport cellular phosphate ion homeostasis sequestering of triglyceride biomineral tissue development negative regulation of protein autophosphorylation cellular response to insulin stimulus negative regulation of fat cell differentiation negative regulation of glycogen biosynthetic process negative regulation of glucose import negative regulation of insulin receptor signaling pathway 3'-phosphoadenosine 5'-phosphosulfate metabolic process nucleic acid phosphodiester bond hydrolysis
It has to be done as per old AB suggested Products section.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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