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OriGene
EGLN2 Monoclonal Antibody (OTI7H3), TrueMAB™
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FIGURE: 1 / 7
EGLN2 Antibody (CF808584) in IHC (P)
Product Details
CF808584
Species Reactivity
Host/Isotype
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Type
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Immunogen
Conjugate
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Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Prolyl hydroxylase domain proteins HIF PHD1, HIF PHD2 and HIF PHD3 (known as PHD1, PHD2 and PHD3 in rodents, respectively) can hydroxylate HIF-alpha subunits. Hypoxia-inducible factor (HIF) is a transcriptional regulator important in several aspects of oxygen homeostasis. The prolyl hydroxylases catalyze the posttranslational formation of 4-hydroxyproline in HIF-alpha proteins. HIF PHD1, which is widely expressed, with highest levels of expression in testis, functions as a cellular oxygen sensor and is important in cell growth regulation. HIF PHD1 can localize to the nucleus or the cytoplasm and is also detected in hormone responsive tissues, such as normal and cancerous mammary, ovarian and prostate epithelium. HIF PHD1 is encoded by EGLN2, which maps to chromosome 19q13. 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Egl nine homolog 2; egl-9 family hypoxia-inducible factor 2; EIT-6; Estrogen-induced tag 6; Falkor; HIF-1alpha prolyl-4-hydroxylase-1; HIF-P4H 1; HIF-PH1; HIF-prolyl hydroxylase 1; HPH-1; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 1; immediate early response 4; P4H1; PHD1; Prolyl hydroxylase domain-containing protein 1; Prolyl hydroxylase EGLN2
Gene Aliases: 0610011A13Rik; C85656; EGLN2; EIT6; Hif-p4h-1; HIF-PH1; HIFPH1; HPH-1; HPH-3; Ier4; PHD-1; PHD1; SM-20
UniProt ID: (Human) Q96KS0, (Mouse) Q91YE2, (Rat) Q6AYU4
Entrez Gene ID: (Human) 112398, (Mouse) 112406, (Rat) 308457
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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