Invitrogen

EDB-FN Chimeric Recombinant Rabbit Monoclonal Antibody (A2)

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Datasheet
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Datasheet
Protocols
Questions & Answers
EDB-FN Chimeric Recombinant Rabbit Monoclonal Antibody (A2)

Product Details

MA5-48023

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

10 µg/mL
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

A2

Immunogen

2D-PAGE gel isolated human Extra-Domain containing fibronectin from lysate of human melanoma COLO-38 cells.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3074466

Product Specific Information

Specificity: This antibody bind to human Extra-Domain containing fibronectin.

Target Information

EDB-FN is a variant of the fibronectin protein that contains an extra domain, known as the extra domain B. This extra domain is not present in the normal fibronectin protein and has been found to be expressed in certain tissues during embryonic development and in tumors. The extra domain has been implicated in cell adhesion, migration, and invasion, and has been shown to play a role in the progression and metastasis of certain cancers. Due to its unique expression pattern and functional properties, EDB-FN has been investigated as a potential target for cancer therapy and imaging.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CIG; Cold-insoluble globulin; extra domain B; extra domain B of fibronectin; Fibronectin; FN; migration-stimulating factor

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Gene Aliases: CIG; ED-B; FINC; FN; FN1; FNZ; GFND; GFND2; LETS; MSF

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UniProt ID: (Human) P02751

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Entrez Gene ID: (Human) 2335

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Function(s)
protease binding integrin binding protein binding collagen binding heparin binding peptidase activator activity identical protein binding mercury ion binding
Process(es)
angiogenesis cell activation regulation of protein phosphorylation platelet degranulation response to ischemia acute-phase response cell-substrate junction assembly cell adhesion calcium-independent cell-matrix adhesion positive regulation of cell proliferation glial cell migration regulation of cell shape response to wounding response to ozone positive regulation of gene expression positive regulation of peptidase activity peptide cross-linking extracellular matrix disassembly extracellular matrix organization integrin activation substrate adhesion-dependent cell spreading cellular response to vascular endothelial growth factor stimulus endodermal cell differentiation cellular response to platelet-derived growth factor stimulus wound healing negative regulation of apoptotic process positive regulation of axon extension positive regulation of fibroblast proliferation leukocyte migration positive regulation of chemotaxis response to glucocorticoid regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to mercury ion cellular response to glucose stimulus cellular response to interleukin-1 cellular response to prostaglandin E stimulus cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus positive regulation of substrate-dependent cell migration, cell attachment to substrate negative regulation of transforming growth factor-beta secretion
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