Invitrogen

Dystrophin Recombinant Rabbit Monoclonal Antibody (10G10K7)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Dystrophin Recombinant Rabbit Monoclonal Antibody (10G10K7)

Product Details

MA5-42861

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10G10K7

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 3586-3685 of human Dystrophin (P11532).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912002

Product Specific Information

Immunogen sequence: LESQLHRLRQ LLEQPQAEAK VNGTTVSSPS TSLQRSDSSQ PMLLRVVGSQ TSDSMGEEDL LSPPQDTSTG LEEVMEQLNN SFPSSRGRNT PGKPMREDTM

Target Information

Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immunohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: apodystrophin-3; apodystrophin-I; Duchenne muscular dystrophy (DMD); Dystrophin; dystrophin Dp40; dystrophin Dp71a; dystrophin Dp71ab; dystrophin Dp71b; dystrophin, muscular dystrophy; GS1-19O24.1; Muscular dystrophy Duchenne and Becker types; OTTHUMP00000215592; X-linked muscular dystrophy

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Gene Aliases: Dmd; DNADMD1; Dp427; Dp71; DXSmh7; DXSmh9; dys; mdx; pke

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UniProt ID: (Mouse) P11531, (Rat) P11530

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Entrez Gene ID: (Mouse) 13405, (Rat) 24907

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Function(s)
dystroglycan binding actin binding structural constituent of cytoskeleton protein binding zinc ion binding structural constituent of muscle myosin binding vinculin binding metal ion binding nitric-oxide synthase binding integrin binding PDZ domain binding protein complex binding
Process(es)
positive regulation of cell-matrix adhesion regulation of heart rate regulation of transcription, DNA-templated muscle organ development skeletal muscle tissue development establishment of blood-nerve barrier regulation of gene expression regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of neuron projection development regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of skeletal muscle contraction myotube cell development muscle attachment olfactory nerve structural organization negative regulation of peptidyl-serine phosphorylation cellular protein localization response to muscle stretch regulation of membrane potential peptide biosynthetic process cellular protein complex assembly neurotransmitter receptor metabolic process positive regulation of neuron differentiation muscle cell cellular homeostasis muscle fiber development nucleus localization cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity establishment of glial blood-brain barrier negative regulation of ERK1 and ERK2 cascade cardiac muscle cell action potential regulation of cellular response to growth factor stimulus regulation of voltage-gated calcium channel activity negative regulation of peptidyl-cysteine S-nitrosylation positive regulation of sodium ion transmembrane transporter activity aging cell differentiation muscle cell differentiation neuron projection morphogenesis
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