Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
Dystroglycan Monoclonal Antibody (2B1G12), CoraLite® Plus 488
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
CL488-66735
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Excitation/Emission Max
Form
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: VGEKSWVQFN SNSQLMYGLP DSSHVGKHEY FMHATDKGGL SAVDAFEIHV HRRPQGDRAP ARFKAKFVGD PALVLNDIHK KIALVKKLAF AFGDRNCSTI TLQNITRGSI VVEWTNNTLP LEPCPKEQIA GLSRRIAEDD GKPRPAFSNA LEPDFKATSI TVTGSGSCRH LQFIPVVPPR RVPSEAPPTE VPDRDPEKSS EDDVYLHTVI PAVVVAAILL IAGIIAMICY RKKRKGKLTL EDQATFIKKG VPIIFADELD DSKPPPSSSM PLILQEEKAP LPPPEYPNQS VPETTPLNQD TMGEYTPLRD EDPNAPPYQP PPPFTAPMEG KGSRPKNMTP YRSPPPYVPP
Target Information
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: alpha-dystroglycan; beta-dystroglycan; Dystroglycan; Dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1
Gene Aliases: 156DAG; A3a; AGRNR; D9Wsu13e; DAG; DAG1; DG; Dp427; Dp71; MDDGA9; MDDGC7; MDDGC9
UniProt ID: (Human) Q14118, (Mouse) Q62165
Entrez Gene ID: (Human) 1605, (Mouse) 13138, (Rat) 114489
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support