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Invitrogen
Dopamine beta Hydroxylase Polyclonal Antibody
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Product Details
PA3-925
Species Reactivity
Published species
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Type
Immunogen
Conjugate
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RRID
Product Specific Information
PA3-925 detects human, bovine, rat and mouse DBH. This antibody is not effective for immunohistochemistry in human brain.
PA3-925 has been successfully used in Western blot, immunohistochemistry and immunofluorescence procedures. By Western blot, this antibody detects an ~72 kDa protein representing DBH from rat neurons. In immunohistochemistry and immunofluorescence procedures, it specifically stains chromaffin cells of the adrenal medulla, and DBH containing cells of the sympathetic nervous system.
The PA3-925 immunogen is a synthetic peptide corresponding to residues S(43) E P P E S P F P Y H I P L D P E G T L(62) of rat DBH. This sequence is highly conserved (>85% homology) in human, bovine and mouse.
Target Information
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Dopamine beta hydroxylase (dopamine beta-monooxygenase); Dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenase; Dopamine-Beta-hydroxylase
Gene Aliases: BOS_12212; DBH; DBM; DOPBHY
UniProt ID: (Human) P09172, (Bovine) P15101, (Rat) Q05754, (Mouse) Q64237
Entrez Gene ID: (Human) 1621, (Bovine) 280758, (Rat) 25699, (Mouse) 13166
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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