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  • Desmoplakin Antibodies
Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

Invitrogen

Desmoplakin Recombinant Superclonal™ Antibody (14HCLC)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Cite Desmoplakin Recombinant Superclonal™ Antibody (14HCLC)

  • Antibody Testing Data (1)
Desmoplakin Antibody in Immunocytochemistry (ICC/IF)
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Desmoplakin Antibody in Immunocytochemistry (ICC/IF)
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Desmoplakin Antibody (711223) in ICC/IF

Immunofluorescence analysis was performed on fixed and permeabilized A-431 cells for detection of endogenous Desmoplakin /DSP using Anti-Desmoplakin /DSP Recombinant Rabbit Superclonal™ Antibody (Product # 711223, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were s... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Desmoplakin Antibody in Immunocytochemistry (ICC/IF)
Desmoplakin Recombinant Superclonal™ Antibody (14HCLC)

Product Details

711223

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Superclonal

Type

Antibody

Clone

14HCLC

Immunogen

Protein corresponding to Human DSP (aa 1970-2270)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2633135

Product Specific Information

This antibody is predicted to react with Monkey, Cat and Mouse

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

Target Information

Desmoplakin (DSP) is a major high molecular weight protein of the desmosomes. It is involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Desmoplakin mutations are associated with Keratoderma and cardiomyopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; Desmoplakin II; Desmoplakin-I; DP

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Gene Aliases: DCWHKTA; DP; DSP

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UniProt ID: (Human) P15924

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Entrez Gene ID: (Human) 1832

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Function(s)
protein kinase C binding structural molecule activity structural constituent of cytoskeleton protein binding protein binding, bridging poly(A) RNA binding cell adhesion molecule binding cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication scaffold protein binding
Process(es)
desmosome organization ventricular compact myocardium morphogenesis epidermis development peptide cross-linking keratinocyte differentiation adherens junction organization wound healing intermediate filament organization protein localization to adherens junction bundle of His cell-Purkinje myocyte adhesion involved in cell communication regulation of heart rate by cardiac conduction regulation of ventricular cardiac muscle cell action potential
It has to be done as per old AB suggested Products section.
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