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Invitrogen
Desmoglein 3 Polyclonal Antibody
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FIGURE: 1 / 1
Desmoglein 3 Antibody (PA5-121194) in WB
Product Details
PA5-121194
Species Reactivity
Host/Isotype
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Immunogen
Conjugate
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Product Specific Information
Positive test controls include: HeLa, Mouse liver. The target is usually found in the following locations: Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome.
Immunogen sequence: FGAATGVGIC SSGQSGTMRT RHSTGGTNKD YADGAISMNF LDSYFSQKAF ACAEEDDGQE ANDCLLIYDN EGADATGSPV GSVGCCSFIA DDLDDSFLDS LGPKFKKLAE ISLGVDGEGK EVQPPSKDSG YGIESCGHPI EVQQTGFVKC QTLSGSQGAS ALSTSGSVQP AVSIPDPLQH GNYLVTETYS ASGSLVQPST AGFDPLLTQN VIVTERVICP ISSVPGNLAG PTQLRGSHTM LCTEDPCSRL I
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 130 kDa pemphigus vulgaris antigen; Cadherin family member 6; Desmoglein-3; DKFZp686P23184; PVA
Gene Aliases: CDHF6; DSG3; PVA
UniProt ID: (Human) P32926
Entrez Gene ID: (Human) 1830
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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