Invitrogen

DVL1 Polyclonal Antibody

View all (12) DVL1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
DVL1 Polyclonal Antibody

Product Details

PA5-142878

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence C-PQLEEAPLTVKSD.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2933521

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Target Information

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1; Dishevelled-1; Dishevelled-1-like; DSH homolog 1; DSH homolog 1-like; MGC54245; RP5-890O3.5; Segment polarity protein dishevelled homolog DVL-1

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Gene Aliases: DRS2; DVL; DVL1; DVL1L1; DVL1P1; mKIAA4029

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UniProt ID: (Human) O14640, (Mouse) P51141

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Entrez Gene ID: (Human) 1855, (Mouse) 13542

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Function(s)
molecular_function frizzled binding protein binding beta-catenin binding enzyme binding protein kinase binding identical protein binding Rac GTPase binding
Process(es)
regulation of neurotransmitter levels positive regulation of protein phosphorylation transcription from RNA polymerase II promoter negative regulation of protein kinase activity neurotransmitter secretion axon guidance synapse assembly heart development neuromuscular junction development positive regulation of neuron projection development neural tube development convergent extension involved in neural plate elongation positive regulation of Wnt signaling pathway cytoplasmic microtubule organization negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein localization to nucleus social behavior protein localization to microtubule intracellular signal transduction receptor clustering positive regulation of transcription, DNA-templated collateral sprouting axon extension dendrite morphogenesis synapse organization protein stabilization canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway prepulse inhibition skeletal muscle acetylcholine-gated channel clustering negative regulation of canonical Wnt signaling pathway cochlea morphogenesis planar cell polarity pathway involved in neural tube closure positive regulation of canonical Wnt signaling pathway positive regulation of protein localization to synapse regulation of cellular protein localization beta-catenin destruction complex disassembly
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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