Invitrogen

DVL1 Polyclonal Antibody

View all (12) DVL1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
DVL1 Polyclonal Antibody

Product Details

PA5-102836

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human DVL1(Accession O14640), corresponding to amino acid residues C382-R432.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2852226

Product Specific Information

Antibody detects endogenous levels of total DVL1.

Target Information

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dishevelled 1; dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1; Dishevelled-1; Dishevelled-1-like; DSH homolog 1; DSH homolog 1-like; MGC54245; RP5-890O3.5; Segment polarity protein dishevelled homolog DVL-1

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Gene Aliases: DRS2; DVL; dvl-1; DVL1; DVL1L1; DVL1P1; mKIAA4029

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UniProt ID: (Human) O14640, (Rat) Q9WVB9, (Mouse) P51141

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Entrez Gene ID: (Human) 1855, (Rat) 83721, (Mouse) 13542

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Function(s)
molecular_function frizzled binding protein binding beta-catenin binding enzyme binding protein kinase binding identical protein binding Rac GTPase binding
Process(es)
regulation of neurotransmitter levels regulation of protein phosphorylation negative regulation of protein phosphorylation positive regulation of protein phosphorylation transcription from RNA polymerase II promoter negative regulation of protein kinase activity neurotransmitter secretion axonogenesis axon guidance neuromuscular junction development positive regulation of neuron projection development Wnt signaling pathway neural tube development convergent extension involved in neural plate elongation positive regulation of Wnt signaling pathway cytoplasmic microtubule organization negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein localization to nucleus social behavior protein localization to microtubule intracellular signal transduction receptor clustering positive regulation of transcription, DNA-templated collateral sprouting axon extension dendrite morphogenesis synapse organization convergent extension involved in organogenesis canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway prepulse inhibition skeletal muscle acetylcholine-gated channel clustering cochlea morphogenesis planar cell polarity pathway involved in neural tube closure positive regulation of canonical Wnt signaling pathway synapse assembly heart development protein stabilization negative regulation of canonical Wnt signaling pathway positive regulation of protein localization to synapse regulation of cellular protein localization beta-catenin destruction complex disassembly
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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