Invitrogen

DNMT1 Monoclonal Antibody (A3A8)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
DNMT1 Monoclonal Antibody (A3A8)

Product Details

MA5-36110

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:400
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

A3A8

Immunogen

Synthetic peptide within Human Dnmt1 aa 500-600
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 0.2% BSA, 50% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2890304

Target Information

This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CXXC-type zinc finger protein 9; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; Dnmt1; FLJ16293; MCMT; MGC104992

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Gene Aliases: ADCADN; AIM; CXXC9; DNMT; DNMT1; HSN1E; m.HsaI; MCMT

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UniProt ID: (Human) P26358

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Entrez Gene ID: (Human) 1786

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Function(s)
DNA binding double-stranded DNA binding RNA binding DNA (cytosine-5-)-methyltransferase activity protein binding zinc ion binding methyl-CpG binding DNA-methyltransferase activity protein domain specific binding estrogen receptor binding histone deacetylase binding unmethylated CpG binding DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter DNA methylation transcription, DNA-templated Ras protein signal transduction brain development aging response to heat response to toxic substance response to ionizing radiation maintenance of DNA methylation DNA methylation on cytosine within a CG sequence positive regulation of gene expression response to activity gene silencing covalent chromatin modification neuron differentiation response to caffeine response to estradiol response to lipopolysaccharide response to vitamin A response to testosterone cellular response to platelet-derived growth factor stimulus response to antidepressant regulation of cell proliferation DNA hypermethylation response to ethanol negative regulation of gene expression, epigenetic S-adenosylhomocysteine metabolic process S-adenosylmethioninamine metabolic process S-adenosylmethionine metabolic process positive regulation of histone H3-K4 methylation negative regulation of histone H3-K9 methylation cellular response to amino acid stimulus cellular response to lead ion cellular response to transforming growth factor beta stimulus C-5 methylation of cytosine positive regulation of methylation-dependent chromatin silencing cellular response to nerve growth factor stimulus
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