Invitrogen

DNMT1 Recombinant Rabbit Monoclonal Antibody (1K5K8)

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Datasheet
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Datasheet
Protocols
Questions & Answers
DNMT1 Recombinant Rabbit Monoclonal Antibody (1K5K8)

Product Details

MA5-35340

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:4,000
-

Immunohistochemistry (IHC)

-
- -

ELISA (ELISA)

1 µg/mL
-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

1K5K8

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DNMT1 (NP_0013701)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849241

Product Specific Information

Immunogen sequence: MPARTAPARV PTLAVPAISL PDDVRRRLKD LERDSLTEKE CVKEKLNLLH EFLQTEIKNQ LCDLETKLRK EELSEEGYLA KVKSLLNKDL SLENGAHAYN

Target Information

This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CXXC-type zinc finger protein 9; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase (cytosine-5) 1; DNA methyltransferase HsaI; DNA methyltransferase I; DNA methyltransferase MmuI; DNA MTase HsaI; DNA MTase MmuI; DNA MTase RnoIP; Dnmt1; FLJ16293; m.RnoIP; MCMT; MGC104992

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Gene Aliases: ADCADN; AIM; CXXC9; DNMT; DNMT1; Dnmt1o; HSN1E; m.HsaI; m.MmuI; MCMT; Met-1; Met1; MommeD2; MTase; Uim

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UniProt ID: (Human) P26358, (Mouse) P13864

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Entrez Gene ID: (Human) 1786, (Rat) 84350, (Mouse) 13433

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Function(s)
DNA binding double-stranded DNA binding RNA binding DNA (cytosine-5-)-methyltransferase activity protein binding zinc ion binding methyl-CpG binding DNA-methyltransferase activity protein domain specific binding estrogen receptor binding histone deacetylase binding unmethylated CpG binding DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates promoter-specific chromatin binding chromatin binding transcription factor binding methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity catalytic activity transferase activity metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter DNA methylation transcription, DNA-templated regulation of transcription, DNA-templated brain development aging response to heat response to toxic substance response to organic substance response to ionizing radiation maintenance of DNA methylation response to lead ion DNA methylation on cytosine within a CG sequence regulation of gene expression positive regulation of gene expression response to activity gene silencing chromatin modification neuron differentiation response to caffeine response to nutrient levels response to estradiol response to lipopolysaccharide DNA methylation on cytosine response to vitamin A response to testosterone cellular response to platelet-derived growth factor stimulus response to antidepressant regulation of cell proliferation response to drug DNA hypermethylation response to ethanol negative regulation of transcription, DNA-templated S-adenosylhomocysteine metabolic process S-adenosylmethioninamine metabolic process S-adenosylmethionine metabolic process positive regulation of histone H3-K4 methylation negative regulation of histone H3-K9 methylation cellular response to amino acid stimulus cellular response to lead ion cellular response to transforming growth factor beta stimulus C-5 methylation of cytosine cellular response to nerve growth factor stimulus Ras protein signal transduction covalent chromatin modification negative regulation of gene expression, epigenetic positive regulation of methylation-dependent chromatin silencing metabolic process methylation
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