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Invitrogen
DLL4 Polyclonal Antibody
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FIGURE: 1 / 5
DLL4 Antibody (PA5-46974) in ICC/IF
Product Details
PA5-46974
Species Reactivity
Published species
Host/Isotype
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Type
Immunogen
Conjugate
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Product Specific Information
In direct ELISAs, approximately 50% cross-reactivity with recombinant human DLL4 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Delta-like protein 4; Delta4; Drosophila Delta homolog 4; MGC126344
Gene Aliases: Delta4; Dll4
UniProt ID: (Mouse) Q9JI71
Entrez Gene ID: (Mouse) 54485
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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