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Proteintech
DKK3 Polyclonal Antibody, CoraLite® Plus 647
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Product Details
CL647-10365
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Excitation/Emission Max
Form
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: ALSYPQEEAT LNEMFREVEE LMEDTQHKLR SAVEEMEAEE AAAKASSEVN LANLPPSYHN ETNTDTKVGN NTIHVHREIH KITNNQTGQM VFSETVITSV GDEEGRRSHE CIIDEDCGPS MYCQFASFQY TCQPCRGQRM LCTRDSECCG DQLCVWGHCT KMATRGSNGT ICDNQRDCQP GLCCAFQRGL LFPVCTPLPV EGELCHDPAS RLLDLITWEL EPDGALDRCP CASGLLCQPH SHSLVYVCKP TFVGSRDQDG EILLPREVPD EYEVGSFMEE VRQELEDLER SLTEEMALGE PAAAAAALLG GEEI
Target Information
DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Dickkopf; dickkopf 3; dickkopf 3 homolog; Dickkopf gene 3; dickkopf homolog 3; Dickkopf-3; Dickkopf-related protein 3; Dickkopf3; DKK 3; dkk-3; hDkk 3; hDkk-3; hhDkk3; mDkk-3; regulated in glioma; RIG-like 5-6; RIG-like 7-1; Xenopus
Gene Aliases: AW061014; C87148; DKK3; REIC; RIG; UNQ258/PRO295
UniProt ID: (Human) Q9UBP4, (Mouse) Q9QUN9
Entrez Gene ID: (Human) 27122, (Mouse) 50781
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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