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Progen
Cytokeratin 18 Monoclonal Antibody (Ks18.5)
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Product Details
65137PROGEN
Species Reactivity
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Conjugate
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Product Specific Information
Ks 18.5 represents an excellent marker to discriminate simple epithelia from those of different origin. Polypeptide reacting: MW 45 000 polypeptide (keratin K18; formerly also designated cytokeratin 18) of all simple type and complex epithelia.Tumors specifically detected: All adeno-CA tested; undifferentiated CA; cervix CA; hepatocellular CA.Reactivity on cultured cell lines: MCF-7, HeLa. A-431, PLC, RT 112. This antibody was used in a Indirect ELISA.
Target Information
Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Cell proliferation-inducing gene 46 protein; CK 18; CK-18; cytokeratin 18; Cytokeratin-18; Cytokeratin18; K 18; K18; keratin 18, type I; Keratin, type I cytoskeletal 18; Keratin-18; Keratin18; KRT 18; type I cytoskeletal 18
Gene Aliases: BOS_5019; CK-18; CYK18; K18; KRT18; PIG46
UniProt ID: (Human) P05783
Entrez Gene ID: (Bovine) 506480, (Human) 3875
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