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Invitrogen
Cyclophilin B Monoclonal Antibody (11C11)
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FIGURE: 1 / 9
Cyclophilin B Antibody (MA5-49248) in ICC/IF
Product Details
MA5-49248
Species Reactivity
Host/Isotype
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Conjugate
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Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human placenta tissue, U-87MG whole cell, HepG2 whole cell, Caco-2 whole cell, SW620 whole cell, PANC-1 whole cell, THP-1 whole cell, HEK293 whole cell, rat spleen tissue, rat lung tissue, mouse spleen tissue, mouse lung tissue. IHC: human oesophagus squama cancer tissue, human ovarian cancer tissue, human placenta tissue, human tonsil tissue, human lung cancer tissue. ICC/IF: U20S cell. Flow: U20S cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Cyclophilin B; cyclophilin-like protein; Cyp B; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; Rotamase; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP
Gene Aliases: AA408962; AA553318; AI844835; Cphn-2; Cphn2; CyP-20b; CYP-S1; CYPB; HEL-S-39; OI9; PPIB; SCYLP
UniProt ID: (Human) P23284, (Rat) P24368, (Mouse) P24369
Entrez Gene ID: (Human) 5479, (Rat) 64367, (Mouse) 19035
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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