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Invitrogen
Cyclophilin A Polyclonal Antibody
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FIGURE: 1 / 9
Cyclophilin A Antibody (PA5-28089) in ICC/IF
Product Details
PA5-28089
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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RRID
Product Specific Information
Recommended positive controls: HepG2, Raji WCE, Raji C+M, Raji NE, mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%), Cat (100%), Pig (100%), Sheep (100%), Rhesus Monkey (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p; HGNC:9253; MGC117158; MGC12404; MGC23397; p1B15; p31; Peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIase; PPIase A; rotamase; Rotamase A; SP18; T cell cyclophilin
Gene Aliases: 2700098C05; Cphn; CYCA; CyP-18; CyP-A; CYPA; CYPH; HEL-S-69p; I79_011869; PPIA
UniProt ID: (Human) P62937, (Mouse) P17742, (Chinese hamster) P14851, (Rat) P10111
Entrez Gene ID: (Human) 5478, (Mouse) 268373, (Chinese hamster) 100769490, (Rat) 25518
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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