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Invitrogen
Complement C5a Monoclonal Antibody (295108)
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FIGURE: 1 / 1
Complement C5a Antibody (MA5-23910) in Neu
Product Details
MA5-23910
Species Reactivity
Host/Isotype
Class
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Clone
Immunogen
Conjugate
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RRID
Product Specific Information
In Western blots, this antibody does not cross-react with recombinant mouse Complement Component C3d, recombinant human (rh) Complement Component C3a, or rhComplement Component C5a.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: C4B1; C4B12; C4B2; C4B3; C4B5; C4F; CH; CO4; Complement C5; CPAMD3; DADB-112B14.11; FLJ17816; FLJ17822; FLJ60561; Hemolytic complement; MGC142298; MGC164979
Gene Aliases: C5; C5a; Hc; He
UniProt ID: (Mouse) P06684
Entrez Gene ID: (Mouse) 15139
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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